Propofol versus Thiamylal - Enflurane Anesthesia for

Study Objective: To determine whether propofol anesthesia diJfers from thiamylaler$urane anesthesia in induction characteristics, intraoperative hemodynamics, postoperative side effects, and postoperative psychomotor function recovery. Design: A randomized, double-blind, two-group study. Setting: A large university hospita1 with gynecologic outpatient operations performed irl un integrated operating room suite. Patients: Sixty adult women (ASA physical status I or II) undergoing an outpatient <gynecoloffc laparoscopic operation with an, anesthesia time qf approximately 60 minutes. Interventions: NO pharmacoloCq’c premedication. Pretreatment with intraveneus droperìdol 0.6 mg and sufentanil 0.2 kglkg before induction of anesthesia. Anesthesia was induced with either thiamylal 4 mglkg (Group 1) or propofo12.5 mglkg (Group 2). Aneslhesia was maintained with either nitrom oxide (N,O) and enflurune, 2-0.5s inspired concenlrations; (Group 1) or with a continuous infusion of propofol200-100 pglkglmin and NyO (Group 2). Measurements and Main Kesults: In psychomotor function tests (Trieger dot test and p-deletion test) administered preoperatively and postoperatively, no differente was ,found between Ihe groups. NO diff erence was found in induction time, although significant& more patients reported pain after the propofol injection, or in intraoperative hemodynamics (mean arterial pressure and heart rate). Immediate recovery time (emergence from anesthesia) and intermediate recovery time (ambulation, oral intake, and dischaige time) were significantly shorter after propofol anesthesia. Fewer postoperative side effects, such as nausea and vomiting, were reported after propofol anesthesia. ConClusions: Induction and maintenance of anesthesia with propofol were comparable to those with thiamylul-enflurane, except patients experienced more pain on injection after propofol. Both immediate and intermediate recovery were more rapid after propofol anesthesia compared with enjlurane-based anesthesia.